COMU is a high efficiency coupling reagent.  The superior reactivity of COMU can be observed by comparing the yields of difficult Aib-Aib coupling performed with the different coupling reagents.  COMU can be utilized with the same protocols as HBTU and HATU.  In applications where racemization is a significant concern, only one equivalent of base can be used because the morpholino group of COMU acts as an internal base.  To order COMU, sign in and CLICK HERE.