Fmoc-Cys(Acm)-OH [86060-81-3] HEADING_TITLE


Catalog #: AFC106 CAS #: 86060-81-3
Formula: C21H22N2O5S M.W.: 414.5









Fmoc-Cys(Acm)-OH is often utilized in preparing peptides containing disulfide bridges.  The Acm protecting group can be removed and the disulfide bond formed simultaneously using iodine (C. G. Joseph, et al., J. Med. Chem., 2004, 47, 6702-10).  This deprotection/cyclization can be performed on resin (Technical Support Bulletin 1180).  The Acm group can also be removed without disulfide bond formation by using Hg(OAc)2 (E. de Oliveira, et al., Bioconjugate Chem., 2003, 14, 144-52).  Acm deprotection protocols are available in Technical Support Bulletin 1123.

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