Fmoc-D-Cys(Acm)-OH [168300-88-7] HEADING_TITLE


Catalog #: AFC206 CAS #:168300-88-7
Formula: C21H22N2O5S M.W.: 414.5









Fmoc-D-Cys(Acm)-OH was utilized to prepare cyclic opioid peptide antagonists (Y. Lu, et al., J. Med. Chem., 2006, 49, 5382-5).  It was also used in the preparation of a nuclease-resistant IRS1 siNRA conjugated to a disufide-bridged D-peptide analog of insulin-like growth factor.  The conjugatew was effective in knocking down expression of IRS-1 in breast cancer cells (G. Cesarone, et al., Bioconjugate Chem., 2007, 18, 1831-40).  Fmoc-D-Cys(Acm)-OH was also utilized to prepare a 111In-labeled PNA-disuulfide bridged D-peptide conjugate for imaging human pancreatic cancer (N. V. Amirkhanov, et al., Bioconjugate Chem., 2010, 21, 731-40).  

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