Fmoc-Phe(4-NO2)-OH [95753-55-2] HEADING_TITLE

N-Fmoc-4-nitro-L-phenylalanine

Other Names: Fmoc-Phe(p-NO2)-OH; Fmoc-para-nitrophenylalanine

Catalog Number: UFF125 CAS Number: 95753-55-2
Formula: C24H20N2O6 M.W.: 432.4

Fmoc-Phe(4-NO2)-OH

 

 

 

 

 

 

 

 

 

 

 

Fmoc-Phe(4-NO2)-OH is uilized to prepare peptides for kinetics studies and SAR studies.  The Phe(4-NO2) residue can be used as a chromogenic label as in a substrate used to develop an [Ile40]HTLV-1 protease inhibition assay (HO Kumada, et al., J. Pept. Sci., 2011, 17, 569-75).  It has also be utilized with pyrenylalanine in FRET studies (H Poras, et al., Appl. Environ. Microbiol., 2009, 75, 4382-90; N Luciani, et al., Biochem. J., 2001, 356(Pt 3), 813-9).  Phe(4-NO2) has also been paired with Trp in FRET studies (ML Tsao, et al., J. Am. Chem. Soc., 2006, 128, 4572-3).  More recently, Phe(4-NO2) has been used as an infrared absorption probe (C Peggion, et al., J. Pept. Sci., 2013, 19, 246-56; EE Smith, et al., J. Phys. Chem. B, 2011, 115, 2380-5).

4-Substituted Phenylalanines

H-Bip-OH   Boc-Bip-OH   Fmoc-Bip-OH
H-D-Bip-OH   Boc-D-Bip-OH   Fmoc-D-Bip-OH
H-Bpa-OH   Boc-Bpa-OH   Fmoc-Bpa-OH
H-D-Bpa-OH   Boc-D-Bpa-OH   Fmoc-D-Bpa-OH
H-Phe(4-Br)-OH   Boc-Phe(4-Br)-OH   Fmoc-Phe(4-Br)-OH
H-D-Phe(4-Br)-OH   Boc-D-Phe(4-Br)-OH   Fmoc-D-Phe(4-Br)-OH
H-Phe(4-Cl)-OH   Boc-Phe(4-Cl)-OH   Fmoc-Phe(4-Cl)-OH
H-D-Phe(4-Cl)-OH   Boc-D-Phe(4-Cl)-OH   Fmoc-D-Phe(4-Cl)-OH
H-Phe(4-F)-OH   Boc-Phe(4-F)-OH   Fmoc-Phe(4-F)-OH
H-D-Phe(4-F)-OH HCl   Boc-D-Phe(4-F)-OH   Fmoc-D-Phe(4-F)-OH
H-Phe(4-I)-OH   Boc-Phe(4-I)-OH   Fmoc-Phe(4-I)-OH
H-D-Phe(4-I)-OH   Boc-D-Phe(4-I)-OH   Fmoc-D-Phe(4-I)-OH
H-Phe(4-CN)-OH   Boc-Phe(4-CN)-OH   Fmoc-Phe(4-CN)-OH
H-D-Phe(4-CN)-OH   Boc-D-Phe(4-CN)-OH   Fmoc-D-Phe(4-CN)-OH
H-Phe(4-Me)-OH   Boc-Phe(4-Me)-OH   Fmoc-Phe(4-Me)-OH
H-D-Phe(4-Me)-OH   Boc-D-Phe(4-Me)-OH   Fmoc--D-Phe(4-Me)-OH
H-Phe(4-CF3)-OH   Boc-Phe(4-CF3)-OH   Fmoc-Phe(4-CF3)-OH
H-D-Phe(4-CF3)-OH   Boc-D-Phe(4-CF3)-OH   Fmoc-D-Phe(4-CF3)-OH
H-Phe(4-NO2)-OH   Boc-Phe(4-NO2)-OH   Fmoc-Phe(4-NO2)-OH
H-D-Phe(4-NO2)-OH   Boc-D-Phe(4-NO2)-OH   Fmoc-D-Phe(4-NO2)-OH
H-Phe(4-NH2)-OH   Boc-Phe(4-NH2)-OH   Fmoc-Phe(4-NH2)-OH
H-D-Phe(4-NH2)-OH   Boc-D-Phe(4-NH2)-OH   Fmoc-D-Phe(4-NH2)-OH
        Fmoc-Phe(4-NHBoc)-OH
     


Fmoc-D-Phe(4-NHBoc)-OH

MSDS