Fmoc-Phe(4-F)-OH [169243-86-1] HEADING_TITLE

N-Fmoc-4-fluoro-L-phenylalanine

Other Names: Fmoc-Phe(p-F)-OH; Fmoc-para-fluoro-phenylalanine

Catalog Number: UFF121 CAS Number: 169243-86-1
Formula: C24H20FNO4 M.W.: 405.4

Fmoc-Phe(4-F)-OH

 

 

 

 

 

 

 

 

 

 

 

Fmoc-Phe(4-F)-OH is utilized to prepare peptides containing Phe(4-F) residues.  These residues are often inserted in place of Phe residues as probes in 19F-NMR (H. Li, C Frieden, J. Biol. Chem., 2005, 280, 38556-61; JG Bann, C Frieden, Biochemistry, 2004, 43, 13775-86).  The dipeptide prolyl-m-sarcolysyl-p-fluorophenylalanine (PSF) has shown promising results agaist human melanoma in mice (KM Dierickx, et al., Pigment Cell Melanoma Res., 2008, 21, 439-50).  Also, studies indicate that the integration of Phe(4-F) residues within protein materials can be employed to tune the material properties, especially mechanical integrity (C Yuvienco, et al., Biomacromolecules, 2012, 13, 2273-8).

Fluorinated Phenylalanines

Cat. # Product Cat. # Product Cat. # Product
UHF120 H-Phe(2-F)-OH UBF120 Boc-Phe(2-F)-OH UFF120 Fmoc-Phe(2-F)-OH
UHF220 H-D-Phe(2-F)-OH HCl UBF220 Boc-Phe(2-F)-OH UFF220 Fmoc-Phe(2-F)-OH
UHF142 H-Phe(3-F)-OH UBF142 Boc-Phe(3-F)-OH UFF142 Fmoc-Phe(3-F)-OH
UHF242 H-D-Phe(3-F)-OH UBF242 Boc-Phe(3-F)-OH UFF242 Fmoc-Phe(3-F)-OH
UHF121 H-Phe(4-F)-OH UBF121 Boc-Phe(4-F)-OH UFF121 Fmoc-Phe(4-F)-OH
UHF221 H-D-Phe(4-F)-OH UBF221 Boc-Phe(4-F)-OH UFF221 Fmoc-Phe(4-F)-OH
UHF146 H-Phe(3,4-diF)-OH UBF146 Boc-Phe(3,4-diF)-OH UFF146 Fmoc-Phe(3,4-diF)-OH
UHF246 H-D-Phe(3,4-diF)-OH UBF246 Boc-D-Phe(3,4-diF)-OH UFF246 Fmoc-D-Phe(3,4-diF)-OH
UHF144 H-Phe(3,5-diF)-OH UBF144 Boc-Phe(3,5-diF)-OH UFF144 Fmoc-Phe(3,5-diF)-OH
UHF244 H-D-Phe(3,5-diF)-OH UBF244 Boc-D-Phe(3,5-diF)-OH UFF244 Fmoc-D-Phe(3,5-diF)-OH

4-Substituted Phenylalanines

H-Bip-OH   Boc-Bip-OH   Fmoc-Bip-OH
H-D-Bip-OH   Boc-D-Bip-OH   Fmoc-D-Bip-OH
H-Bpa-OH   Boc-Bpa-OH   Fmoc-Bpa-OH
H-D-Bpa-OH   Boc-D-Bpa-OH   Fmoc-D-Bpa-OH
H-Phe(4-Br)-OH   Boc-Phe(4-Br)-OH   Fmoc-Phe(4-Br)-OH
H-D-Phe(4-Br)-OH   Boc-D-Phe(4-Br)-OH   Fmoc-D-Phe(4-Br)-OH
H-Phe(4-Cl)-OH   Boc-Phe(4-Cl)-OH   Fmoc-Phe(4-Cl)-OH
H-D-Phe(4-Cl)-OH   Boc-D-Phe(4-Cl)-OH   Fmoc-D-Phe(4-Cl)-OH
H-Phe(4-F)-OH   Boc-Phe(4-F)-OH   Fmoc-Phe(4-F)-OH
H-D-Phe(4-F)-OH HCl   Boc-D-Phe(4-F)-OH   Fmoc-D-Phe(4-F)-OH
H-Phe(4-I)-OH   Boc-Phe(4-I)-OH   Fmoc-Phe(4-I)-OH
H-D-Phe(4-I)-OH   Boc-D-Phe(4-I)-OH   Fmoc-D-Phe(4-I)-OH
H-Phe(4-CN)-OH   Boc-Phe(4-CN)-OH   Fmoc-Phe(4-CN)-OH
H-D-Phe(4-CN)-OH   Boc-D-Phe(4-CN)-OH   Fmoc-D-Phe(4-CN)-OH
H-Phe(4-Me)-OH   Boc-Phe(4-Me)-OH   Fmoc-Phe(4-Me)-OH
H-D-Phe(4-Me)-OH   Boc-D-Phe(4-Me)-OH   Fmoc--D-Phe(4-Me)-OH
H-Phe(4-CF3)-OH   Boc-Phe(4-CF3)-OH   Fmoc-Phe(4-CF3)-OH
H-D-Phe(4-CF3)-OH   Boc-D-Phe(4-CF3)-OH   Fmoc-D-Phe(4-CF3)-OH
H-Phe(4-NO2)-OH   Boc-Phe(4-NO2)-OH   Fmoc-Phe(4-NO2)-OH
H-D-Phe(4-NO2)-OH   Boc-D-Phe(4-NO2)-OH   Fmoc-D-Phe(4-NO2)-OH
H-Phe(4-NH2)-OH   Boc-Phe(4-NH2)-OH   Fmoc-Phe(4-NH2)-OH
H-D-Phe(4-NH2)-OH   Boc-D-Phe(4-NH2)-OH   Fmoc-D-Phe(4-NH2)-OH
        Fmoc-Phe(4-NHBoc)-OH
     


Fmoc-D-Phe(4-NHBoc)-OH

MSDS