HOAt [39968-33-7] HEADING_TITLE

1-Hydroxy-7-azabenzotriazole

Catalog #: CXZ012 CAS #: 39968-33-7
Formula: C5H4N4O M.W.: 136.1

HOAt

 

 

 

 

HOAt is used as an additive with HATU or PyAOP in peptide couplings to supress racemization.  It is utilized with carbodiimide reagents to form activated HOAt esters of protected amino acids.  The HOAt esters are more reactive than HOBt esters and coupling is faster.  It has been speculated that this enhancement is due to neighboring group effects (LA Carpino, J. Am. Chem. Soc., 1993, 115, 4397-8).

Products Similar to HOAt

Cat. # Product
CXZ021 Oxyma
CXZ010 HOBt H2O
CXZ096 6-Cl-HOBt
CXZ015 HOOBt
CXZ022 HOSu

MSDS