Boc-Pro-OH [15761-39-4] HEADING_TITLE

N-Boc-L-proline

Other Names: Boc-L-Pro-OH

Catalog #: ABP101 CAS # 15761-39-4
Formula: C10H17NO4 M.W.: 215.2

Boc-Pro-OH

 

 

 

 

Boc-Pro-OH is the proline derivative utilized in Boc SPPS.  Proline is the only standard amino acid having a secondary amine.  Proline does not produce a blue or purple color when reacted with ninhydrin.  To test the completion of coupling to proline residues, the isatin test or one of the alternate tests should be used.  Proline residues within peptides and proteins lack an amide proton and can not function as hydrogen-bond donors.  The conformational rigidity of proline residues normally disrupts alpha helix or beta sheet structure in proteins, but often contributes to turn or loop structures.  Unlike other amino acids, the free enthalpy difference between the cis and trans isomers of the N-Pro amide bond are small and both isomers exist in solution.  Although the free enthalpy difference between cis and trans isomers is small the rotational barrier is quite high.  The cis-trans interconversion os one of the limiting steps in protein folding.  

Products Similar to Boc-Pro-OH

Cat. # Product Cat. # Product
ABP201 Boc-D-Pro-OH AFP101 Fmoc-Pro-OH
ABP105 Boc-Pro-OMe AFP191 Fmoc-Pro-OPfp
ABP220 Boc-D-Pro-OSu AFP201 Fmoc-D-Pro-OH
UBP102 Boc-beta-HPro-OH AFP291 Fmoc-D-Pro-OPfp
UBP202 Boc-D-beta-HPro-OH UFP102 Fmoc-beta-HPro-OH
UBP131 Boc-Azetidine-2-carboxylic acid UFP202 Fmoc-D-beta-HPro-OH
UBP231 Boc-D-Azetidine-2-carboxylic acid UFP131 Fmoc-azetidine-2-carboxylic acid
UBP101 Boc-Hyp-OH UFP231 Fmoc-D-azetidine-2-carboxylic acid
UBP111 Boc-Hyp(Bzl)-OH UFP101 Fmoc-Hyp-OH
UBP103 Boc-Hyp-OMe UFP115 Fmoc-Hyp(tBu)-OH
UBP104 Boc-Hyp-OEt UFP111 Fmoc-Hyp(Bzl)-OH
ABP110 Boc-4-Oxo-Pro-OH UFP106 Fmoc-Oic-OH
ABP115 Boc-4-Oxo-Pro-OMe UFC115 Fmoc-Thz-OH
UBC115 Boc-Thz-OH DFP101 Fmoc-Prolinol
UBC215 Boc-D-Thz-OH AZP101 Z-Pro-OH
DBP201 Boc-D-Prolinol AZP201 Z-D-Pro-OH
    AZP103 Z-Pro-NH2
    DZP101 Z-Prolinol

MSDS