Fmoc-Cys(Trt)-OH [103213-32-7] HEADING_TITLE

N-Fmoc-S-trityl-L-cysteine

Other Names: Fmoc-L-Cys(Trt)-OH; N-Fmoc-S-triphenylmethyl-L-cysteine

Catalog # AFC105 CAS 103213-32-7
Formula C37H31NO4S M.W. 585.7

Fmoc-Cys(Trt)-OH

 

 

 

 

 

 

Fmoc-Cys(Trt)-OH is the cysteine derivative most commonly utilized in solid phase peptide synthesis with Fmoc amino acids.  The trityl group can be removed from the cysteine side chain with trifluoroacetic acid (TFA) leaving an unprotected thiol.  Iodine may be used to remove the trityl group and subsequently form a disulfide bond (Technical Bulletin 1127).  This method is useful for preparing peptides containing disulfide bridges.  Fmoc-Cys(Acm)-OH may be used in conjuction with Fmoc-Cys(Trt)-OH.  Like the trityl group, Iodine can remove the Acm group and oxidize the exposed thiol to disulfide. 

Products Similar to Fmoc-Cys(Trt)-OH

Cat. # Product Cat. # Product
AFC106 Fmoc-Cys(Acm)-OH ABC106 Boc-Cys(Acm)-OH
AFC102 Fmoc-Cys(Bzl)-OH ABC110 Boc-Cys(Bzl)-OH
AFC120 Fmoc-Cys(tBu)-OH ABC115 Boc-Cys(pMeBzl)-OH
AFC125 Fmoc-Cys(pMeBzl)-OH ABC114 Boc-Cys(Mob)-OH
AFC110 Fmoc-Cys(Mmt)-OH ABC112 Boc-Cys(tBu)-OH
AFC125 Fmoc-Cys(Mob)-OH ABC113 Boc-Cys(Trt)-OH
AFC205 Fmoc-D-Cys(Trt)-OH ABC213 Boc-D-Cys(Trt)-OH
AFC206 Fmoc-D-Cys(Acm)-OH ABC125 Boc-Cys(Acm)-ONp
AFC196 Fmoc-Cys(Acm)-OPfp UBC152 Boc-Pen(pMeBzl)-OH
AFC195 Fmoc-Cys(Trt)-OPfp UBC115 Boc-Thz-OH
AFC295 Fmoc-D-Cys(Trt)-OPfp UBC252 Boc-D-Pen(pMeBzl)-OH
UFC172 Fmoc-Pen(Trt)-OH UBC215 Boc-D-Thz-OH
UFC272 Fmoc-D-Pen(Trt)-OH AZC110 Z-Cys(Mob)-OH
UFC115 Fmoc-Thz-OH AZC105 Z-Cys(Z)-OH
MFC105 Fmoc-MeCys(Trt)-OH    

MSDS