Boc-L-Amino Acids HEADING_TITLE

 

Boc-L-amino acids have a long history in solid phase peptide synthesis, being utilized by Bruce Merrifield early in the development of SPPS and they remain popular today. Treatment with trifluoroacetic acid (TFA) removes the Boc group, leaving the N-terminus of the peptide protonated. In the classical solid phase peptide synthesis, the protonated peptide is neutralized with a separate base wash. Kent and Alewood (Alewood, D.; Kent, S.B.H.; et al. Int. J. Peptide Protein Res., 1992, 40, 180-193.) developed Rapid Boc chemistry, which utilizes Boc-amino acid preactivation with HBTU or HATU and in situ neutralization. These protocols have been effective for preparing difficult peptides such as ACP (1-29). Most likely, protonation of the peptide disrupts the hydrogen bonding responsible for aggregation. When neutralized in situ  in the presence of an activated amino acid, the free amine terminal of the peptide couples with the activated amino acid more rapidly than aggregation can occur.

Boc-L-amino acids from AAPPTec are high purity, 99% or greater for most products, and competitively priced. Boc-L-amino acids are available in bulk quantities. Please send an E-mail to AAPPTec at sales@aapptec.com for a quotation or use our On-Line Quotation Request.


A Few of the High Quality Boc-L-Amino Acids Available from AAPPTec:


Boc-Alanine

Boc-Arginine(Tos)

Boc-Aspartic Acid(OBzl)

Boc-Asparagine(Xan)

Boc-Cysteine(Acm)

Boc-Cysteine(4-Mob)

Boc-Glutamic Acid(OBzl)

Boc-Glutamine(Xan)

Boc-Glycine

Boc-Histidine(DNP) 

Boc-Histidine(Tos)

Boc-Isoleucine

Boc-Leucine

Boc-Lysine(Fmoc)

Boc-Lysine(2-Cl-Z)

Boc-Methionine

Boc-Phenylalanine

Boc-Proline

Boc-Serine(Bzl)

Boc-Threonine(Bzl)

Boc-Tryptophan(Formyl)

Boc-Tyrosine(2-Br-Z)

Boc-Tyrosine(Bzl)

Boc-Valine

 

 

Boc-L-Amino Acid