Fmoc-L-Amino Acids HEADING_TITLE

Fmoc-L-Amino Acids were first reported by Carpino in 1970 (Carpino, L.A. and Han, G.Y. J. Am. Chem. Soc. 1970, 92, 5748).  The Fmoc group is removed from Fmoc-amino acids under basic conditions, thus allowing very acid labile resins such as 2-Cl-Trt to be used.  Generally, peptide synthesis and cleavage conditions are milder with Fmoc amino acids than Boc amino acids.  The Fmoc group is usually removed from Fmoc amino acids using piperidine, which removes the Fmoc group and reacts with the deprotection byproduct to prevent undesired side reactions and byproducts.  When deprotection is sluggish, DBU can be used to accelerate the reaction.  As DBU does not react the fulvene byproduct formed during deprotection, piperidine is often added as a scavenger to remove fulvene. DBU promotes aspartimide formation, however, and should not be used when aspartic acid residues are present.

All Fmoc-L-Amino Acids are also available in bulk quantities.  Please send an e-mail to sales@aapptec.com for a quotation or use the On-Line Quote Request.

Some of AAPPTec's fine Fmoc-L-Amino Acids

Fmoc-Alanine

Fmoc-Arginine(Pbf)

Fmoc-Aspartic Acid(OtBu)

Fmoc-Asparagine(Trt)

Fmoc-Cysteine(Trt)

Fmoc-Glutamic Acid(OtBu)

Fmoc-Glutamine(Trt)

Fmoc-Glycine

Fmoc-Histidine(Trt)

Fmoc-Isoleucine

Fmoc-Leucine

Fmoc-Lysine(Boc)

Fmoc-Methionine

Fmoc-Phenylalanine

Fmoc-Proline

Fmoc-Serine(tBu)

Fmoc-Threonine(tBu)

Fmoc-Tryptophan(Boc)

Fmoc-Tyrosine(tBu)

Fmoc-Valine

 

General Fmoc-L-Amino Acid