Fmoc-D-Amino Acids HEADING_TITLE

Fmoc-D-Amino Acids from AAPPTec are greater than 99% pure and competitively priced.  Fmoc-D-amino acids are not used as frequently as the corresponding L-isomers because D-amino acids do not occur in the proteins and peptides produced by higher organisms. However D-amino acids are often found in the peptidoglycans contained in the cell membranes of many microbes.  Many natural and synthetic peptides containing D-amino acids possess strong antimicrobial properties.

Fmoc-D-amino acids are often used in drug development studies.  Beside antimicrobial properties, introducing D-amino acids into a synthetic peptide can make the peptide less susceptible to enzymatic degradation and improves its drug characteristics. For example D-amino acids are often used to increase the stability of a peptide to proteases.  D-amino acids can be incorporated in place of the natural L-amino acids, either at a specific position, or throughout the whole peptide.

Cyclic analogs of small bioactive peptides are being studied as potential drug targets.  These small cyclic peptides often contain at least one D-amino acid.  Including a D-amino acid in the linear precursor peptide promotes efficient cyclization.

AAPPTec offers a wide selection of very high purity, competitively priced Fmoc-D-Amino Acids.  All Fmoc-D-amino acids are available in kilogram or bulk quantities in addition to standard catalog quantities. Please  e-mail AAPPTec at sales@aapptec.com for a bulk quotation or use the On-Line Quotation Request.

Fmoc-D-Alanine

Fmoc-D-Arginine(Pbf)

Fmoc-D-Aspartic Acid

Fmoc-D-Asparagine(Trt)

Fmoc-D-Cysteine(Trt)

Fmoc-D-Glutamic Acid(OtBu)

Fmoc-D-Glutamine(Trt)

Fmoc-D-Histidine(Trt)

Fmoc-D-Isoleucine

Fmoc-D-Leucine

Fmoc-D-Lysine(Boc)

Fmoc-D-Methionine

Fmoc-D-Phenylalanine

Fmoc-D-Proline

Fmoc-D-Serine(tBu)

Fmoc-D-Threonine(tBu)

Fmoc-D-Tryptophan(Boc)

Fmoc-D-Tyrosine(tBu)

Fmoc-D-Valine

 

General Fmoc-D-Amino Acid