Fmoc-Asp(OtBu)-(Dmb)Gly-OH [900152-72-9]

Catalog # NGD105
CAS # [900152-72-9]
Formula C34H38N2O9
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Product Details

N-[N-Fmoc-L-aspartyl(beta t-butyl)]-N-(2,4-dimethoxybenzyl)glycine

The N-Dmb group disrupts hydrogen bonding in the peptide backbone and reduces aggregation. Incorporated into long or difficult peptides, N-Dmb dipeptides can improve peptide yield and purity. When the Dmb protecting group is attached to the amino acid preceeding Asp in a peptide, Dmb blocks aspartimide formation and the side products resulting from aspartimide formation. In SPPS the N-Dmb group is removed with TFA during peptide cleavage from the resin.


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