Eclipse HEADING_TITLE

 

Eclipse™ is a smart new peptide synthesizer providing the peptide chemist and user, for the first time, software which
analyzes any sequence no matter how difficult and provides a protocol. Eclipse™ presents the user with a synthesis
strategy in an easy to interpret graphical display. Our exclusive Smart Synthesis™ software is based on an algorithm
compiled from AAPPTec’s thirty-five years of experience synthesizing difficult peptides.

Eclipse™ is a smart new peptide synthesizer providing the peptide chemist and user, for the first time, software whichanalyzes any sequence no matter how difficult and provides a protocol. Eclipse™ presents the user with a synthesisstrategy in an easy to interpret graphical display. Our exclusive Smart Synthesis™ software is based on an algorithmcompiled from AAPPTec’s thirty-five years of experience synthesizing difficult peptides.

The Eclipse™ is the research scale peptide synthesizer used by novices and experts alike. Researchers need only to enter:

1. peptide sequence & name

2. amount of resin

3. resin substitution

Smart Synthesis Software

The Eclipse Smart Synthesis™ software will automatically generate and carry out the synthesis protocol without additional input. Experienced peptide researchers can create custom protocols including double and single couplings,longer or shorter reaction times or variable temperatures. They can change the number of washes or even utilize different coupling chemistry for each amino acid. While the instrument is running, one can change the protocol without interruption or set up the next synthesis.

The Eclipse™ was developed to automatically provide synthesis protocol and efficient peptide synthesis without additional user input. The Eclipse Smart Synthesis™ software evaluates the peptide sequence and generates a graphical report of the expected difficulty of each amino acid (Figure 1). It predicts when double coupling would be required,thus improving synthesis efficiency. The algorithm also predicts when and where to modify the chemistry either by double coupling, substituting pseudoproline dipeptides, Dmb protected dipeptides or amino acid,double coupling and extended deprotection, etc., thus these modifications improve synthesis efficiency and increase the quality of crude peptide by reducing the side products. The algorithm also suggests the use of different chemistries show a great increase in yield and superior crude peptide.

ECLIPSE FEATURES

• Automatically set-up synthesis

• Smart software predicts difficult sequences and automatically suggests protocol suitable for efficient coupling

• Gives flexibility to the expert chemist to modify protocol

• Precise delivery of amino acids and reagents

• Separate amino acid pre-activation

• Mixing by vortex, N2 bubbling or both combined.

• Heating option available with proven delayed gradient technique

• Low solvent usage

• Low cost of reagent

• Low waste

• All reactor, amino acid containers and reagent bottles are all easily accessible from the front

• Compact footprint

Operational Specifications

• From 10 mg to 500 mg of resin

• Twenty amino acid vessels with multi access capability

• 1 x 2L, 1 x 1L, 2 x 250 ml solvent/reagent bottles

• 110V or 220V electrical connection

• 80 amino acid peptides can be synthesized easily without any interruption

Eclipsen

Synthesis of TymosinFigure 1: Synthesis of Tymosin α1 (SDAAVDTSSEITTKDLKEKKEVVEEAEN-NH2)