The
Endeavor 90 peptide synthesizer offers unparalleled flexibility and
capability in peptide synthesis. These instruments function as a fully
automated peptide synthesizer, while also offering the user complete
control of the synthesis. Solid phase peptide and organic chemistry
reactions, including Boc and Fmoc chemistries, are easy and cost
effective with the Endeavor 90 peptide synthesizer.
Dual
reactors allow simultaneous synthesis of two compounds with different
chemistries in vessel sizes up to 50ml, and permit easy scale-up with
interchangeable vessel sizes up to 2L. Endeavor 90-I peptide
synthesizer comes as standard with two 25ml reaction vessels, but
larger vessels are available for easy scale up. The Endeavor 90-II
peptide synthesizer is a more easily customizable model, and reactor
vessels up to 2L are available for synthesis.
Solvent
is delivered to reaction vessels under nitrogen pressure, regulated to
10psi, to create a totally inert environment - allowing all types of
reactions, including the more difficult synthesis using air- and
water-sensitive reagents, to be performed. Solvent is delivered either
from the top or the bottom of the reaction vessel. All glass and Teflon
reactor vessels are pre-silanized to prevent resin from sticking to the
reactor walls which can lead to deletion. This makes sure each
synthesis produces the highest quality pure product.
Reagent
mixing in the reaction vessel is achieved by one of three optional
mixing settings: nitrogen bubbling from the bottle of the vessel,
variable speed wrist-action shaking, or a combination of both. The rate
of bubbling and the speed of shaking can both be manually altered by
the simple turn of a dial for homogeneous agitation and optimum
synthesis conditions. In addition, magnetic stir bars are available for
the larger size reaction vessels to ensure consistent and reproducible
synthesis at larger scales.
Four
amino acid vessels are provided in the Endeavor 90-I (4 x 90ml) and
Endeavor 90-II (4 x 250ml) peptide synthesizers, in which the amino
acids are stored. These vessels are reusable, and can hold either solid
powder or liquid amino acid preparations - solid amino acids can be
automatically dissolved in the required solvent as part of the
synthesis protocol. During synthesis, these vials can be changed and
refilled with additional amino acids, giving you maximum flexibility
and control to your synthesis. In addition, the amino acids can be
pre-activated in these vessels, adding extra speed to your synthesis.
The
Endeavor 90 peptide synthesizer software was designed by chemists for
chemists, and contains easy to use drag and drop programming features.
Synthesis progression is displayed on screen in color-coded sections
for quick and easy visual reference. As well as permitting the easy
creation of custom protocols, the software contains pre-programmed
optimized standard protocols for both Boc and Fmoc chemistry.
The
Endeavor 90 peptide synthesizer is a reliable and robust instrument
that enables cost-effective usage of bulk reagents for the synthesis of
high quality peptides. This appliance provides variability in scale of
synthesis, sophisticated capabilities at an affordable price and
reproducible high standards of performance in a single tabletop unit.
Key Features
- Two
reactors for dual simultaneous synthesis: 2 x 25ml vessels for Endeavor
90-I peptide synthesizer; variable vessel size in Endeavor 90-II
peptide synthesizer, 5ml-2L capacity
- Variable
scale synthesis: 1-10mmol in Endeavor 90-I peptide synthesizer;
0.1-50mmol in Endeavor 90-II peptide synthesizer (depending on reactor
size)
- Four amino acid vessels: 4 x 90ml in Endeavor 90-I peptide synthesizer, 4 x 250ml in Endeavor 90-II peptide synthesizer
- Reproducible batch to batch synthesis
- Inert nitrogen atmosphere for the use of air- and water-sensitive reagents
- Performs any solid phase peptide or organic chemistry, including Boc and Fmoc chemistries
- Three mixing options: nitrogen bubbling, variable speed wrist action shaking, or both
- No additional hood required, since reaction vessels are enclosed
- Simple point and click software for easy creation of custom protocols, as well as pre-programmed optimized standard protocols
Key Specifications
- One or two reaction vessels
- Four amino acid vessels
- Glass fritted reaction vessels
- Variable scale synthesis, 0.1-50 mmol
- Solvent bottles: 4 x 500ml, 3 x 2L
- Inert nitrogen atmosphere for use of air- and water-sensitive reagents
- High efficient mixing using either or both of nitrogen bubbling and variable speed wristaction shaking
- Pre-silanized glass and Teflon vessels to create non-stick surfaces
- Solid phase peptide and organic chemistry, including Boc and Fmoc chemistries
- Precise
liquid deliveries: wash solvents are transferred to the reaction vessel
by a 'shower head'; reagent solvents are delivered to the bottom