Substituted Amino Acids on Resins

Attaching an amino acid unit onto a resin is a step crucial to the success of solid phase synthesis, especially library synthesis. One problem often encountered in this step is the incomplete reaction of the reactive sites on the resin. Unless they are blocked, these unreacted sites can react with other reagents in later steps of the synthesis and generate impurities that may be difficult to remove. Inefficient attachment of the protected amino acid also lowers the useful substitution, reducing the overall yield and efficiency of the solid phase synthesis. Partial racemization of the protected amino acids is another problem that can occur during the loading reaction.

Numerous catalysts, activating agents, additives and reaction conditions have been tested to find the optimum conditions for substrate-attached resins. As may be expected, these conditions vary for the different resins. aapptec substrate-attached resins are prepared by proven procedures that ensure good substitution and minimize racemization of the substrates. Each substituted resin is end-capped to block any remaining unreacted active resin sites that could interfere later in the synthesis.

aapptec offers an extensive selection of these substituted amino acid resins, each manufactured to fall within the stated ranges. Requests for substitutions outside of these ranges will be considered a custom order; please inquire for details.

aapptec has these classes of substituted amino acid resins:

For more information, please email us at sales@aapptec.com or call us at 888.692.9111.